TopMD was created by a team of scientists and mathematicians at the University of Southampton to dramatically improve precision and accuracy of disease diagnosis. Additionally, TopMD promises to revolutionise healthcare, by allowing high resolution investigation of molecular mechanisms underlying disease, and therefore enabling development of targeted treatments for application in stratified medicine.
Diseases and disease sub-types have characteristic patterns of modulated gene pathways. This is represented in the shape of gene expression measured by standard affordable global gene expression profiling. The revolutionary algorithms applied in TopMD plot the shape of a patient’s gene expression and compares it to the shape of gene expression characteristic of diseases for precise and accurate diagnosis.